Hylenex

The majority of dermal fillers injected worldwide are comprised of HA.

One of the major appeals of the HA fillers is that they are reversible and are temporary. Hyaluronidase, an enzyme found across many species, is the “antidote” used to dissolve the HA fillers. The following conditions are appropriate to use hyaluronidase:

• Undesired cosmetic result
• Nodularity
• Granuloma
• Infected filler
• Vascular compromise (emergency)
• Blindness (emergency)

While there are a many variations of hyaluronidase available in the US (Hylenex, Hydase, Vitrase, Amphadase), the preferred brand at The Aesthetic Clinique is Hylenex. The reason to choose Hylenex is because it is a human recombinant form and is the least likely to have an allergic/anaphylaxis reaction.

Treating filler with Hylenex is not an exact science. There are huge variations in the amount of Hylenex required to dissolve a filler. The important factors to consider are:

• Degree of crosslinking (higher crosslinked fillers are harder to dissolve)
• Time filler has been in body (longer time equates to harder to dissolve)
• Urgency (higher doses are required to resolve emergency situations – in general)
• Inflammatory granuloma or nodules require higher doses
• Individual variations

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Sylvie Hazen

23:13 05 Jun 25

Dr. Weiner, his wife Sandy and their staff are the absolute best. I will never chance going anywhere else. He is the only Dr. I have found that truly has a good eye, and takes one’s features into consideration. The office is beautiful and clean, and everyone is very friendly and welcoming. Love them!

Summer Davis

15:17 21 May 25

I made an appointment for Botox and felt very cared for through the process. They explained everything well to me, listened to what I wanted, and helped me find a good balance of what was “needed” and what I wanted. Looking forward to seeing it set in in the next few days!

Meg Roberts

13:26 17 May 25

I had my first hydro facial ever with Hannah and I am SO glad I did! I didn’t know my skin needed that so badly, and Hannah is so knowledgeable, friendly, and kind. I will definitely be booking with her again!

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A typical Hylenex treatment is less than 5 minutes and very comfortable. The Hylenex is often mixed with lidocaine to improve comfort and leaves the area numb for about 30 minutes. The HA is dissolved within a few hours (sometimes minutes) but there will be some swelling from the injection that can take a day or 2 to resolve. If replacement of filler is desired, this can be performed in 3 days. Likewise, if further treatment is required (in a non-emergency situation), repeat injections are done at 3 days or later.